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Reports Frbiz.com transdermal formulations international market gradually heat

"Give a catchy results reveal a new strategy for transdermal transport of macromolecules," will be used in transdermal enhancer in the display area of phages in vivo research is novel, "the completion of a people who are interested in papers. "March 27, the United States," Nature Biotechnology "magazine Wunlong these observations in the quiet of his study groups.

Ping Wunlong physical sciences at the Micro-USTC, Hefei National Laboratory for the project leader, Professor, College of Life Sciences. Not long ago, he led the research team to be in the original phage display technology vivo transdermal research, and managed to find a 11 amino acids, can effectively assist protein drugs transdermal short peptides.

Studies have shown that such a short peptide and insulin in a simple saline solution to mix and apply on the skin of diabetic rats, which is capable of producing a good hypoglycemic effect. In addition, this peptide may also contribute to human growth hormone patch shows that proteins can have a generic.

According to Professor Wunlong level, the results are obtained in animals, while the peptide patch is equally effective on the human body must still be verified. Currently, the research team works with companies of Shanghai medical technology to conduct pre-clinical studies. transdermal enhancer peptide found in the significance of this is: Over the years, application of chemical penetration enhancers and physical assistance to two major categories of proteins through transdermal drug formulations of macromolecules has had results little progress, if the results of human trials successfully, that will herald the emergence of a huge market.

The international market gradually heat the so-called penetration enhancers are used to enhance transdermal drug delivery (TDS) in the penetration of the drug as a means of Pharmacy. In recent years, researchers have national enthusiastic study of this approach, because once the study is a breakthrough in transdermal formulations, drug delivery will be applied to a wide range of areas, which means that the potential market Transdermal formulations will be vacated.

transdermal preparations derived from 70 years in the last century, its principle is drug absorption through the skin and blood to play a healing effect, it is also known as transdermal preparations, or transdermal delivery system Transdermal System (TTS). This system of delivery of the drug seemed, with its duration, the constant concentration in the blood and controlled to avoid the liver first pass effect, increasing the bioavailability, routes of administration advantages of simple compliance and patient great concern by the market. Currently, the United States and Europe will be the transdermal preparation that the focus of pharmaceutical research.

Transdermal formulations for the birthplace of the United States as an example. It was reported that in 1992 the U.S. market, sales of the nicotine patch to quit smoking 10 million in 2004, the U.S. has more than 35 drugs available transdermal preparations. In 2005, the United States more than 20% of pharmaceutical companies have begun production of TTS. The relevant statistics have shown, the international pharmaceutical company producing transdermal formulations have been dozens of others, about one third of the manufacturers will use the new forms. Currently, the transdermal drug delivery developed by the U.S. share of world-class drugs for 56% of the amount of drug in Europe, accounted for 32%, Japan 7%. Recently, there have been a number of foreign companies listed on the transdermal formulations. Mylan's product first for the treatment of adult patients with severe depression selegiline trans.